Drug repurposing study finds lonafarnib effective against RSV

12

Feb , 2024

Drug repurposing study finds lonafarnib effective against RSV

In a study published in the journal Nature Communications, researchers screened ReFRAME (short for repurposing, focused rescue, and accelerated Medchem), a drug-repurposing library, for drugs against respiratory syncytial virus (RSV). They identified lonafarnib as a potent inhibitor of RSV fusion protein and investigated its therapeutic potential against an RSV infection. Study: Drug repurposing screen identifies […]

23

Oct , 2023

Tag: Respiratory Tract Infections

New insights into why obesity puts individuals at risk for severe influenza

In a recent study published in the journal Nature Communications, researchers used blood and airway sampling of morbidly obese individuals and murine models to elucidate the mechanisms underpinning severe cases of influenza among the obese population. Study: Obesity dysregulates the pulmonary antiviral immune response. Image Credit: Jarun Ontakrai/Shutterstock.com Background Their findings reveal that obesity induces deficits in […]

4

Aug , 2023

Tag: Respiratory Tract Infections

The immunomodulatory and antiviral function of vitamin D

Recently, scientists reviewed the available literature to better understand vitamin D’s immunomodulatory and antiviral function. The study explores how vitamin D influences the pediatric respiratory system after acute respiratory tract infections (ARTI), such as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which is the causal agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. This review […]