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Real Talk on Dating and Relationships
Real Talk on Dating and Relationships
10 Most Expensive Watches on Sotheby’s Right Now
10 Most Expensive Watches on Sotheby’s Right Now
The 18 Best Waterproof Shoes For Men To Keep Your Feet Dry
The 18 Best Waterproof Shoes For Men To Keep Your Feet Dry
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7

Jul , 2024
Breakthrough humanized mouse model offers new insights for immunotherapy development
Tag: Mouse Model

Breakthrough humanized mouse model offers new insights for immunotherapy development

A breakthrough for biomedical research promises new insight into immunotherapy development and disease modeling. Scientists at The University of Texas Health Science Center at San Antonio have created a humanized mouse model with a human immune system and a human-like gut microbiome that is capable of mounting specific antibody responses. The scientists were led by Paolo […]

23

Apr , 2024
Innovative malaria prodrug targets liver, enhances efficacy while reducing toxicity, preclinical studies show
Tag: Mouse Model

Innovative malaria prodrug targets liver, enhances efficacy while reducing toxicity, preclinical studies show

With malaria still posing a constant and often deadly threat to billions worldwide, new therapies are urgently required to combat the infection. This is made more difficult by the multiple stages of the parasite’s lifecycle. A new report in Scientific Advances reports on tafenoquine, a prodrug that could fulfill the criteria for a mass eradication […]

3

Apr , 2024
Researchers find a promising approach to remove amyloid plaques in Alzheimer’s disease
Tag: Mouse Model

Researchers find a promising approach to remove amyloid plaques in Alzheimer’s disease

Alzheimer’s disease starts with a sticky protein called amyloid beta that builds up into plaques in the brain, setting off a chain of events that results in brain atrophy and cognitive decline. The new generation of Alzheimer’s drugs -; the first proven to change the course of the disease -; work by tagging amyloid for […]

10

Mar , 2024
New research identifies potential drug target to prevent kidney failure
Tag: Mouse Model

New research identifies potential drug target to prevent kidney failure

A new study found that retinoic acid receptors (RARa) in the proximal tubules of the kidney play a crucial role in limiting the damaging effects of kidney injury that often lead to kidney failure. Researchers from Weill Cornell Medicine have developed a preclinical model that showed a condition like chronic kidney disease develops when RARa […]

16

Jan , 2024
Nanobots for bladder cancer treatment, promising high efficacy and targeted delivery
Tag: Mouse Model

Nanobots for bladder cancer treatment, promising high efficacy and targeted delivery

Bladder cancer is currently treated in its earlier stages by localized intravesical chemotherapy or immunotherapy after removing the tumor. However, recurrences occur in up to 70% of patients at 5 years, while up to 30% fail to respond. This means a constant need to monitor and retreat these patients, driving costs sky-high for the treatment […]

7

Jan , 2024
Researchers identify mechanism that causes gastrointestinal problems with cancer immunotherapy
Tag: Mouse Model

Researchers identify mechanism that causes gastrointestinal problems with cancer immunotherapy

Researchers at the University of Michigan Health Rogel Cancer Center have identified a mechanism that causes severe gastrointestinal problems with immune-based cancer treatment. They also found a way to deliver immunotherapy’s cancer-killing impact without the unwelcome side effect. The findings are published in Science. This is a good example of how understanding a mechanism […]

10

Sep , 2023
Study evaluating intranasal anti-CD3 for treatment of Alzheimer’s disease published in the PNAS journal
Tag: Mouse Model

Study evaluating intranasal anti-CD3 for treatment of Alzheimer’s disease published in the PNAS journal

Tiziana Life Sciences Ltd. (“Tiziana” or the “Company”), a biotechnology company developing breakthrough immunomodulation therapies via novel routes of drug delivery, today announced acceptance of a publication, “Nasal Administration of anti-CD3 monoclonal antibody (mAb) ameliorates disease in a mouse model of Alzheimer’s disease”, in the preeminent journal, Proceedings of the National Academy of Sciences (PNAS), that […]

14

Jul , 2023
Macrophages may play a major role in the development of atrial fibrillation
Tag: Mouse Model

Macrophages may play a major role in the development of atrial fibrillation

Current treatments for atrial fibrillation (AFib), a common heart condition characterized by fast and irregular beats that can lead to stroke and heart failure, have multiple side effects and are ineffective for preventing AFib recurrence. New research led by investigators at Massachusetts General Hospital (MGH) and published in Science reveals that certain immune cells play […]