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Using AI to break the opioid addiction cycle

When Ben Brown, research assistant professor of chemistry, thinks about the opioid epidemic, he views the problem on a molecular level. Painkillers used legitimately in medicine, such as oxycodone, are highly addictive, but better understanding of how their molecules interact with proteins in the body could lead to the formulation of nonaddictive alternatives, he said. […]

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Study shows Omicron variants evade immune system like predecessors, suggesting key evolutionary trait in SARS-CoV-2

In a recent study in Nature Microbiology, researchers compared severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of concern (VOC) replication in human cell lines and primary airway cultures and measured host responses to infection. Study: Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants. Image Credit: Naeblys/Shutterstock.comBackground SARS-CoV-2 evolution has led to […]

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Novel blood test shows promise in detecting early-stage cancers with high accuracy

In a recent article published in the journal BMJ Oncology, researchers developed a novel proteome/liquid biopsy-based diagnostic test to detect less abundant plasma proteins, i.e., biomarkers for various cancers in human organs. Study: Novel proteomics-based plasma test for early detection of multiple cancers in the general population. Image Credit: ArtemisDiana/Shutterstock.comThe researchers were pursuing the development of […]

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Revolutionary blood test monitors gene expression dynamics in the brain

The brain is the most protected organ in the body, sheathed in a complex and nearly impenetrable barrier of specialized blood vessels. While this particular anatomical setup protects it from outside invaders, it also makes it difficult for researchers to study how specific genes are expressed ⎯ and how such changes in gene expression may […]

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Mettl3 guides CD8 T cells to eliminate infected cells with maximum efficiency

This study is led by Dr. Shuyang Yu (College of Biological Sciences, China Agricultural University), Dr. Jingyu Xu (The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University) and Dr. Xuguang Du (College of Biological Sciences, China Agricultural University) and illustrated the key role of Mettl3 in CD8 T cell […]

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Boosting protein stability and resilience with interlocking rings

This study is led by Prof. Wen-Bin Zhang (College of Chemistry and Molecular Engineering, Peking University & Beijing Academy of Artificial Intelligence) and Dr. Jing Fang (College of Chemistry and Molecular Engineering, Peking University). A single-domain protein catenane refers to two mechanically interlocked polypeptide rings that fold synergistically into a compact and integrated structure, which […]

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“NK cell-engaging nanodrones” can selectively target and kill cancer cells

A groundbreaking study led by Professor Sebyung Kang and Professor Sung Ho Park in the Department of Biological Sciences at UNIST has unveiled a remarkable breakthrough in cancer treatment. The research team has successfully developed unprecedented “NK cell-engaging nanodrones” capable of selectively targeting and eliminating cancer cells, offering a potential solution for intractable types of […]

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‘Visual system’ protein appears to be key for stabilizing the body’s circadian rhythms

Scientists at the Johns Hopkins University School of Medicine and the National Institutes of Health have identified a protein in the visual system of mice that appears to be key for stabilizing the body’s circadian rhythms by buffering the brain’s response to light. The finding, published Dec. 5 in PLoS Biology, advances efforts to better […]

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New combination treatment offers hope for older patients with mantle cell lymphoma

The phase 2 trial PrE0405 met its primary endpoint, achieving a complete response (CR) rate of 85% in 33 patients over the age of 60 with mantle cell lymphoma (MCL) who received bendamustine and rituximab, a standard chemo-immunotherapy treatment, along with venetoclax, which is investigational in this setting. The combination was generally well-tolerated, a notable […]

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