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8 of the best men’s shoes for summer from HEYDUDE
8 of the best men’s shoes for summer from HEYDUDE
The Billionaire Clobber Revolution – Why the Men Are Boring and the Riviera Is Blooming
The Billionaire Clobber Revolution – Why the Men Are Boring and the Riviera Is Blooming
The Compassionate Warrior: The Power of Mature Masculine Psychology
The Compassionate Warrior: The Power of Mature Masculine Psychology
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11

Jul , 2024
Novel molecule could inform new therapies for stroke-related brain injury
Tag: Membrane

Novel molecule could inform new therapies for stroke-related brain injury

A newly developed molecule, LK-2, could inform new therapies for stroke-related brain injury, finds scientists at The Hospital for Sick Children (SickKids).  An ischemic stroke occurs when blood flow to a part of the brain is interrupted, depriving the brain cells of oxygen and nutrients. Without timely treatment, brain cells can die, resulting in permanent […]

25

Jun , 2024
Novel genetic predisposition to being overweight or obese identified
Tag: Membrane

Novel genetic predisposition to being overweight or obese identified

In a recent study published in Med, researchers performed a case-control study to compare metabolic changes between individuals homozygous for a loss-of-function (LoF) genetic variation in small integral membrane protein 1 (SMIM1) and the general population. Study: SMIM1 absence is associated with reduced energy expenditure and excess weight. Image Credit: james benjamin/Shutterstock.com Background Obesity is […]

12

Feb , 2024
Drug repurposing study finds lonafarnib effective against RSV
Tag: Membrane

Drug repurposing study finds lonafarnib effective against RSV

In a study published in the journal Nature Communications, researchers screened ReFRAME (short for repurposing, focused rescue, and accelerated Medchem), a drug-repurposing library, for drugs against respiratory syncytial virus (RSV). They identified lonafarnib as a potent inhibitor of RSV fusion protein and investigated its therapeutic potential against an RSV infection. Study: Drug repurposing screen identifies […]

13

Oct , 2023
The penetration of antidepressants into cells, organelles, and membranes
Tag: Membrane

The penetration of antidepressants into cells, organelles, and membranes

In a recent review published in the journal Neuropsychopharmacology, a group of authors elucidated the intracellular dynamics of antidepressants, challenging the traditional extracellular interaction perspective by exploring their chemical and pharmacological properties and evaluating their subcellular activity and distribution characteristics. Study: Antidepressants enter cells, organelles, and membranes. Image Credit: Christoph Burgstedt / Shutterstock Background  Since the early […]

4

Sep , 2023
Study characterizes SARS-CoV-2 subvariants to inform development of next-generation COVID-19 vaccines
Tag: Membrane

Study characterizes SARS-CoV-2 subvariants to inform development of next-generation COVID-19 vaccines

In a recent preprint posted to the bioRxiv* server, researchers characterized two novel XBB variants, EG.5.1 and XBB.2.3, with the former on track to become the dominant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant. Study: Immune Evasion and Membrane Fusion of SARS-CoV-2 XBB Subvariants EG.5.1 and XBB.2.3. Image Credit: Kateryna Kon/Shutterstock.com*Important notice: bioRxiv publishes preliminary […]

19

Aug , 2023
RARα receptor plays unexpected role in T cell activation
Tag: Membrane

RARα receptor plays unexpected role in T cell activation

According to new research in the journal Immunity, T cells have a nuclear receptor doing something very odd-;but very important-;to help them fight pathogens and destroy cancer cells. This receptor, called retinoic acid receptor alpha (RARα), is known to control gene expression programs in the nucleus, but it also now appears to operate outside the […]

7

Aug , 2023
3D analysis of inner ear provides insights into Ménière’s disease
Tag: Membrane

3D analysis of inner ear provides insights into Ménière’s disease

Elaborate 3D analysis of the inner ear now, for the first time, provide insights into volume changes of special structures in sufferers of the so-called Ménière’s disease. The cause of this rare disease remains unclear to this day, although it leads to severe balance disorders, among other things. A successful collaboration between the Karl Landsteiner […]

6

Aug , 2023
Study helps understand how RNA modification promotes pancreatic cancer
Tag: Membrane

Study helps understand how RNA modification promotes pancreatic cancer

Chemical modifications of RNA molecules, such as m6A, can critically impact gene expression, influencing various aspects of cancer development and progression. However, while studies into m6A modification of messenger RNA (mRNA) have been extensive, exploration of its impact on lncRNAs, especially within the context of PDAC, has been relatively limited. In an innovative study published […]