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Novel bispecific antibodies show promise against evolving SARS-CoV-2 variants

In a recent research paper uploaded to the bioRxiv preprint* server, researchers developed and tested novel bispecific antibodies (bsAbs) comprising both the N-terminal domain (NTD) and the receptor binding domain (RBD) for their efficacy against emergent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs). These antibodies were synthesized using monoclonal antibodies (mAbs) […]

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Clinical trial shows CRISPR gene editing has exciting potential to treat a rare form of blindness

Retinal degeneration can be inherited or acquired. In the former case, it is an incurable and progressive condition. A recent study published in The New England Journal of Medicine investigated the potential use of gene editing to correct a congenital retinal degeneration called CEP290 that causes early-onset vision loss. Study: Gene Editing for CEP290-Associated Retinal Degeneration. Image […]

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CRISPR gene editing shows promise for treating individuals with a form of inherited blindness

Results from a groundbreaking clinical trial of CRISPR gene editing in 14 individuals with a form of inherited blindness show that the treatment is safe and led to measurable improvements in 11 of the participants treated. The phase 1/2 trial called BRILLIANCE, was led by principal investigator Eric Pierce, MD, PhD, of Mass Eye and […]

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New influenza vaccine strategies aim to enhance protection with T-cell responses

In a recent review published in the journal Nature Reviews Immunology, researchers discussed the limitations of current influenza vaccines and the potential for future vaccines to induce both T-cell responses and antibodies for enhanced protection. They examined the strategies to develop influenza vaccines with broad strain specificity and long-term efficacy, covering protection requirements, immune response […]

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Innovative malaria prodrug targets liver, enhances efficacy while reducing toxicity, preclinical studies show

With malaria still posing a constant and often deadly threat to billions worldwide, new therapies are urgently required to combat the infection. This is made more difficult by the multiple stages of the parasite’s lifecycle. A new report in Scientific Advances reports on tafenoquine, a prodrug that could fulfill the criteria for a mass eradication […]

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Korean fermented food Doenjang shows promise in alleviating menopausal symptoms

In a recent study published in the journal Nutrients, researchers compare the efficacy between traditional and commercial Doenjang in alleviating menopausal syndrome. Study: Evaluation of menopausal syndrome relief and anti-obesity efficacy of the Korean fermented food doenjang: a randomized, double-blind clinical trial. Image Credit: mino choi / Shutterstock.com Treating menopause Menopause leads to hormonal changes that may […]

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Annual COVID-19 vaccine proves to be a wise investment for personal health and pocketbook

In a recent study published in The Journal of Infectious Diseases, a team of researchers from the United States (U.S.) attempted to understand whether individuals experienced any economic benefits in getting an annual coronavirus disease 2019 (COVID-19) vaccine, given that the morbidity and mortality rates associated with the disease have decreased and the government no […]

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Lerodalcibep reduces LDL cholesterol by over 50% in high-risk patients

Among patients at high or very high risk for a heart attack or stroke, the addition of the investigational drug lerodalcibep to standard cholesterol-lowering medication for one year reduced LDL, or “bad” cholesterol, levels by more than half on average, compared with a placebo. In addition, 90% of patients treated with lerodalcibep, versus 16% of […]

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Mar , 2024

Mediterranean diet linked to lower dementia risk, finds extensive review

In a recent study published in the journal Aging Clinical and Experimental Research, researchers evaluated the link between the Mediterranean diet (MedDiet) and reduced dementia risk in older adults through a systematic review and meta-analysis. Study: Association between Mediterranean diet and dementia and Alzheimer disease: a systematic review with meta-analysis. Image Credit: luigi giordano Background Dementia, […]

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Mar , 2024