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Records show Publix opioid sales grew even as addiction crisis prompted other chains’ pullback

An executive at Teva Pharmaceuticals flagged Publix Super Markets in October 2015 after detecting what he called in an email “serious red flags” with the grocery chain’s orders of powerful opioids. The share of high-strength oxycodone orders was well above normal for a chain of grocery store pharmacies, and the total number of pills sent […]

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Using AI to break the opioid addiction cycle

When Ben Brown, research assistant professor of chemistry, thinks about the opioid epidemic, he views the problem on a molecular level. Painkillers used legitimately in medicine, such as oxycodone, are highly addictive, but better understanding of how their molecules interact with proteins in the body could lead to the formulation of nonaddictive alternatives, he said. […]

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Trump official who OK’d drugs from Canada chairs company behind Florida’s import plan

The Food and Drug Administration’s unprecedented approval of Florida’s plan to import drugs from Canada was made possible only after Alex Azar, as the Trump administration’s Health and Human Services secretary, certified that bringing medicines over the border could be done safely. Azar made the historic declaration in September 2020, just two months before his […]

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Eastern equine encephalitis virus study uncovers decoy molecule that protects against deadly brain infection

An atomic-level investigation of how Eastern equine encephalitis virus binds to a key receptor and gets inside of cells also has enabled the discovery of a decoy molecule that protects against the potentially deadly brain infection, in mice. The study, from researchers at Washington University School of Medicine in St. Louis, is published Jan. 3 […]

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Researchers reveal a connection between cellular metabolism and depression, suicidal ideation

Major depressive disorder affects 16.1 million adults in the United States and costs $210 billion annually. While the primary symptoms of depression are psychological, scientists and doctors have come to understand that depression is a complex disease with physical effects throughout the body. For example, measuring markers of cellular metabolism has become an important approach […]

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Protective genetic variant shields Black Americans from kidney disease risk

Many Black Americans who are thought to have a high risk of developing kidney disease possess a protective genetic variant that nullifies the extra risk, a new study from Columbia researchers has found. The study found that high-risk people who carry this variant have a risk of developing kidney disease much closer to that of […]

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EULAR publishes updated recommendations for SLE management

SLE is a heterogeneous disease, which can cause many different manifestations and symptoms, and traditionally did not have many treatment options. However, the picture is changing, and clinical practice must change accordingly, to keep up with modern treatment options and to make the most of new drugs that can target key pathophysiological pathways. In line […]

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HDAC inhibitors may offer new strategy for reversing fibrotic wall around pancreatic tumors

Pancreatic cancer is one of the deadliest cancers-;only about one in eight patients survives five years after diagnosis. Those dismal statistics are in part due to the thick, nearly impenetrable wall of fibrosis, or scar tissue, that surrounds most pancreatic tumors and makes it hard for drugs to access and destroy the cancer cells. Now, […]

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