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PharmaKure announces epigenetics collaboration with Sheffield Hallam University to understand mechanisms of Alzheimer’s Diseases

PharmaKure, a clinical stage pharmaceutical company developing precision medicines for Alzheimer’s Disease and other neurodegenerative diseases, today announces a new epigenetics collaboration with Sheffield Hallam University. This partnership will focus on ‘gene-based environmental biomarkers,’ known as epigenetic markers, for calculating risk scores for Alzheimer’s disease. Together with ALZmetrixTM, PharmaKure’s blood-based biomarker, this will increase the […]

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Aventa Genomics and the Future of Genomic Testing

In this interview, Chris Roberts of Aventa Genomics highlights the groundbreaking Aventa FusionPlus test, detailing its superior ability to detect gene fusions in cancer diagnostics and its pivotal role in advancing personalized oncology treatments. Could you give us a brief overview of Aventa Genomics, including its founding vision and primary mission in the field of […]

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Hormonal steroids found to boost drug resistance in gonorrhea bacteria

In a recent study published in Nature Communications, researchers performed cellular, biochemical, and structural analyses to assess the multiple transferable resistance repressor (MtrR) binding and activation by male and female steroidal hormones, physiologically significant molecules interacting with gonococcal organisms during infection. Neisseria gonorrhoeae is a gram-negative diplococcus that causes millions of diseases globally, including those […]

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New vaccine may be potential off-the-shelf treatment for pancreatic, colorectal cancer

A new vaccine shows encouraging early results as a potential off-the-shelf treatment for certain patients with pancreatic or colorectal cancer, according to a study co-led by researchers at Memorial Sloan Kettering Cancer Center (MSK). The vaccine targets tumors with mutations (or changes) in the KRAS gene, a driving force in many cancers. This cancer vaccine is different from another type […]

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Weill Cornell Medicine researcher wins $2.1 million grant to study repetitive DNA and RNA sequences

Dr. Jeannine Gerhardt, an assistant professor of stem cell biology in obstetrics and gynecology and in reproductive medicine at Weill Cornell Medicine, has received a five-year, $2.1 million grant from the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health, for the study of repetitive DNA and RNA sequences and […]

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Increased milk intake associated with a decreased risk of type 2 diabetes in adults who do not produce lactase

The researchers of a recent study published in Nature Metabolism investigated the relationship between milk consumption and type 2 diabetes (T2D) among lactase non-persistent (LNP) individuals. Study: Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetes. Image Credit: Yurii_Yarema/Shutterstock.comBackground Cow’s milk is part of the human diet; however, […]

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Ancient DNA traces multiple sclerosis origins to 5,000-year-old migrations

Researchers have created the world’s largest ancient human gene bank by analyzing the bones and teeth of almost 5,000 humans who lived across Western Europe and Asia up to 34,000 years ago. By sequencing ancient human DNA and comparing it to modern-day samples, the international team of experts mapped the historical spread of genes – […]

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Air pollution may affect male reproduction via oxidative stress, says study

In a recent review published in Antioxidants, researchers described the implications of exposure to air pollutants on male fertility parameters and sexual health. They further discussed the potential clinical effects of air pollution on male reproductive outcomes and the role of oxidative stress in the process. Study: Implications of Exposure to Air Pollution on Male Reproduction: […]

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Dec , 2023

Exploring the effects of N1-methylpseudouridine in mRNA translation

In a recent study published in Nature, a group of researchers explored how the incorporation of N1-methylpseudouridine (1-methylΨ) into messenger ribonucleic acids (mRNAs) affects ribosomal frameshifting and the overall fidelity of mRNA translation. Study: N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting. Image Credit: MattL_Images/Shutterstock.comBackground Therapeutic in vitro-transcribed (IVT) mRNAs, like those in COVID-19 vaccines, often […]

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Dec , 2023