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Revolutionizing High-Throughput Genomic Sample Preparation

Solution Reduces Workflow Time From Hours to Minutes. Image Credit: Beckman Coulter Life Sciences INDIANAPOLIS – (June 18, 2024) – Beckman Coulter Life Sciences, a global leader in laboratory automation and innovation, accelerates high-throughput genomic sample preparation workflows to deliver results faster with the launch of its Biomek Echo One System. The new solution […]

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Innovative blood test boosts accuracy of lung cancer screening

In a recent study published in Cancer Discovery, researchers developed and validated a blood-based, cell-free deoxyribonucleic acid (cfDNA) fragmentome assay for lung cancer detection, which, if the results were positive, would be followed by low-dose computed tomography (LDCT). Study: Clinical validation of a cell-free DNA fragmentome assay for augmentation of lung cancer early detection. Image Credit: MMD […]

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Novel combination treatment outperforms standard therapy in patients with EGFR NSCLC

The combination of the antibody amivantamab and lazertinib, a drug targeting EGFR, shows better clinical benefits compared to standard treatment in patients with advanced or metastatic non-small cell lung cancer with EGFR gene mutations who also present one of these poor prognostic markers: brain and/or liver metastases, p53 gene co-mutations, or the presence of circulating […]

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key to reducing heart disease and mortality through epigenetics

In a recent study published in the Journal of the American Heart Association, researchers investigated whether Deoxyribonucleic Acid (DNA) methylation-based epigenetic age biomarkers mediate the associations between Life’s Essential 8 (LE8) score and risks of cardiovascular disease (CVD), CVD-specific mortality, and all-cause mortality. Study: Epigenetic Age Mediates the Association of Life’s Essential 8 With Cardiovascular Disease […]

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hnRNPM’s protective role in protein synthesis precision uncovered

Researchers at Baylor College of Medicine and collaborating institutions have discovered that a protein called hnRNPM helps protect the integrity of the process cells use to make proteins. hnRNPM works by preventing the cell from making mistakes while it is putting together the different components leading to newly produced proteins. In cancer cells, loss of […]

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Researchers produce advanced multidimensional maps of gene regulation networks in the brain

A consortium of researchers has produced the largest and most advanced multidimensional maps of gene regulation networks in the brains of people with and without mental disorders. These maps detail the many regulatory elements that coordinate the brain’s biological pathways and cellular functions. The research, supported the National Institutes of Health (NIH), used postmortem brain […]

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Ancient viral sequences in the human genome may contribute to psychiatric disorder susceptibility

New research led by King’s College London has found that thousands of DNA sequences originating from ancient viral infections are expressed in the brain, with some contributing to susceptibility for psychiatric disorders such as schizophrenia, bipolar disorder, and depression. Published in Nature Communications, the study was part-funded by the National Institute for Health and Care […]

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Natural compounds in gut microbiome show promise for inflammation treatment

Researchers at the University of Toronto have found naturally occurring compounds in the gut that can be harnessed to reduce inflammation and other symptoms of digestive issues. This can be achieved by binding the compounds to an important, but poorly understood, nuclear receptor. The gut microbiome hosts bacteria that produce compounds as by-products of feeding on our […]

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Mar , 2024

New England Biolabs® Launches NEBNext® Enzymatic 5hmC-seq Kit, for enzyme-based 5hmC detection at single-base resolution

New England Biolabs (NEB®) today announced the launch of the NEBNext Enzymatic 5hmC-seq Kit (E5hmC-seq™), a novel enzyme-based method for the specific detection of 5hmC sites. The gentle, enzyme-based approach enables high yields and high-quality data, with an input range of 100 pg to 200 ng. While the biological importance of 5hmC modification is less clear […]

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Mar , 2024